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Mitochondrial damage associated with apoptosis and necrosis can release damage-associated molecular pattern molecules (DAMPs) and histones that activate inflammatory pathways to exacerbate the lung disease ( FIGURE 1 2.1 Mechanisms of mitochondrial dysfunction Mitochondrial dysfunction can arise through a wide array of genetic and environmental factors and has been implicated in a wide variety of pathological states

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Nicotine Can Elevate Blood Glucose Nicotine acts as a stimulant and can cause a temporary spike in blood sugar levels

Histamine is inflammatory for example, meaning its likely to worsen symptoms such as a blocked nose